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AI agents on foundation models often misapply healthcare and life sciences decision frameworks, citing the right guideline but applying it incorrectly. This post shares 38 open-source agent skills across 11 HCLS domains that close this gap, with installation steps, three worked use cases, and a 410-prompt evaluation showing a 70-86% win rate.
Integrate NVIDIA Resiliency Extension (NVRx) into PyTorch FSDP training on Amazon EKS to overlap checkpoint I/O with training and recover from GPU faults in seconds. This post covers async checkpointing, in-process restart, and ft_launcher in-job restart, with H100 benchmarks at 2 to 8 nodes showing 99%+ training efficiency and second-scale recovery.
AgentCore optimization turns production traces into proposed configuration changes, then validates them before promotion. This technical companion to the launch post explains how the system prompt optimizer's reflector engine works and shares benchmark results for the Single Agent and Sub-Agent Reflectors.
Learn how to automate end-to-end PII detection and redaction from scanned documents at scale using Amazon Bedrock Data Automation with a custom blueprint, AWS Step Functions, and AWS Lambda. A custom blueprint redacts sensitive fields with field-level precision, and a token matching quality check raises recall across degraded and handwritten documents.
An agentic society is a collection of AI agents that coordinate autonomously across trust boundaries, on behalf of different principals whose objectives may only partially align. We show experimentally that in agentic societies even honest, competent agents often fail to reach satisfactory outcomes with existing harnesses and messaging primitives, and that faulty or malicious agents can stall collaboration, influence outcomes, and pursue other harmful goals by exploiting vulnerabilities in communication (``speech''). We argue that agentic societies need a \emph{social harness} for inter-agent interactions, in addition to each agent's \emph{personal harness}, which manages its private context and communication with its principal. We propose a layered architecture for social harnesses which (i) prevents classes of failures outright, (ii) enables agents to detect invalid messages at runtime, and (iii) supports post-facto investigation and consequences, and highlight directions for future research to realize these capabilities.
We introduce and release ScienceBuddy, an interactive scientific research workspace that brings continually improving scientific agents into researchers' everyday workflows. ScienceBuddy supports researchers in carrying out scientific tasks while transforming their requests, feedback, and execution evidence into tasks and evaluation rubrics for continual learning. At its core is recursive-in-recursive self-improvement, a paradigm that couples harness evolution with model reinforcement learning: the inner recursion improves the harness with the model fixed, while the outer recursion trains the model under the improved harness. Harness evolution shapes training experience, and model learning creates new opportunities for harness adaptation. We present case studies of researcher interaction, harness refinement, and model learning, with the benchmark cases spanning four scientific task families. By releasing ScienceBuddy as a research product, we make this paradigm available to the scientific community and take a step toward discovery intelligence: scientific AI that advances through sustained collaboration with researchers and evolves alongside the research it supports. Website: http://science-buddy.io
Interactive control for video generation is moving from coarse prompts toward fine-grained, physically meaningful manipulation of dynamic scenes. Yet existing controllable methods either require the full control schedule before generation starts, or use pixel-space signals that dictate object positions rather than physical dynamics. To address these limitations, we propose PhysStream, an autoregressive model for physics-grounded image-to-video synthesis that incorporates structured scene memory---positional maps and object tracking maps derived online from previously generated frames---and supports fine-grained motion control via sparse velocity-increment signals that encode physical quantities, letting the model learn the underlying dynamics. We train our model in two stages: a bidirectional model is first finetuned with motion-control conditioning, then a causal autoregressive model is trained with additional structured scene memory, further improving physical consistency. PhysStream enables interactive, mid-generation control over multi-object tabletop rigid-body scenes---a capability not supported by prior methods---reducing motion distribution distance (FVMD) by 33% and trajectory error by 12% over the strongest baselines on synthetic benchmarks, and is preferred by human evaluators in over 85% of in-the-wild comparisons. Please check our website for more details: https://czzzzh.github.io/PhysStream
Large language models can produce fluent answers when their factual support is weak. This paper introduces Chain-of-Self-Questioning (CoSQ), a prompt-only framework that makes answer commitment conditional on an explicit assessment of the information required to answer a question. We evaluate three CoSQ variants under seventeen conditions on the 817-item TruthfulQA multiple-choice validation set using eleven open-weight and hosted model families. In the final balanced-option protocol, Grounded-CoSQ at τ=0.90 reduces the mean unconditional wrong-commitment rate from 13.1% under chain-of-thought prompting to 8.9%, a 32.1% relative reduction, while increasing answered accuracy from 86.9% to 89.7% and answering 87.6% of questions. Both improvements hold for all eleven models and at every evaluated threshold. Critical-CoSQ and Adaptive-CoSQ provide neighboring operating points with 88.6% and 86.5% coverage, respectively, while remaining more reliable than the baseline. A secondary Natural Questions Short-Answer evaluation provides convergent open-form evidence. These findings show that self-assessment can support explicit, tunable answer-or-abstain decisions when an unsupported commitment is more costly than referral or review.
Pruning can reduce the deployment cost of large language models (LLMs), but its impact on context-grounded tool calling remains poorly understood. We systematically study pruning-induced degradation in smart-home tool calling across four LLMs spanning dense Transformer, dense hybrid, and mixture-of-experts (MoE) architectures, together with depth, width, hybrid, and expert pruning methods. After post-pruning supervised fine-tuning (SFT), we evaluate more than 19,500 instances from three smart-home datasets. Beyond aggregate task accuracy, we characterize degradation along two dimensions: action components (i.e., operation, device, argument, and value) and task complexity. Our results show that dense models have narrow safe pruning regions followed by sharp degradation, while MoE models tolerate substantially more pruning. Pruning degrades grounded specificity before schema-level intent, and aggressive dense pruning can induce systematic over-refusal. These findings highlight the importance of evaluating pruning beyond aggregate accuracy when selecting pruned LLMs for reliable tool execution.
Neural audio codecs are a key component in speech language modeling. However, their high frame rates lead to long sequence lengths, increasing computational costs. Dynamic frame rate codecs mitigate this by reducing the effective frame rate using a compression step to merge multiple frames together. However, most prior methods either operate on single-codebook codecs or apply a single compression step before multi-layer quantization. This forces all quantization layers to share the same segmentation boundaries, despite the residual embeddings at different quantization layers exhibiting different rates of change over time. We propose LACE (Layer-Adaptive Codec Encoding), a dynamic frame rate codec that applies an independent compression step at each quantization layer, enabling layer-specific segmentation boundaries. To use LACE tokens in downstream text-to-speech (TTS), we further introduce union alignment and boundary anchor mechanisms to make durations consistent across layers while preserving compression benefits. Experiments on LibriTTS show that LACE offers a better rate-quality tradeoff than prior dynamic frame rate methods on the reconstruction task and improves TTS inference efficiency while maintaining competitive synthesis quality. Our code is released as part of the ESPnet3 codec recipe.
Uncertainty estimation for Vision-Language-Navigation (VLN) models is a critical task since it can help identify ambiguous and unreliable predictions, enabling agents to make safer navigation decisions. As one of the most advanced uncertainty estimation frameworks, conformal prediction (CP) offers a promising approach for uncertainty estimation in VLN. However, given that VLN agent requires a sequence of steps, standard calibration in conformal prediction fails to provide coverage guarantee it promises over a dependent, variable-length VLN episode. To this end, we propose Episode-Normalized Conformal Prediction (ENCP), which rescales a nonconformity score by the policy's residual confidence and calibrates one maximum score per episode. Under exchangeable calibration and test episodes, this construction covers the ground truth at every step with probability at least $1 - α$, while allowing dependence among steps within an episode. Across four VLN policies and three nonconformity scores on R2R and REVERIE dataset, ENCP meets all reported empirical step-coverage targets on the seen-to-unseen evaluation. These results demonstrate that ENCP can provide model-agnostic uncertainty estimates, which might be useful for determining when a VLN agent should defer to a more capable predictor, including human assistance.
LLM assistants are widely used for daily social advice, yet evaluating their social reasoning in such consultation settings remains challenging since (i) it requires setups where the assistant learns about social situations from subjective user narratives, and (ii) social properties, such as others' intentions, typically lack verifiable ground truth. To address these challenges, we introduce Fuse, a multi-agent simulation framework for studying user-mediated social reasoning. In Fuse, a target agent with a hidden motive interacts with other agents including one representing the user, who then consults the evaluated assistant to infer the target's motive, providing verifiable ground truth by construction. Simulation faithfulness is validated through a human study with 24k annotations. We apply Fuse to 12 LLMs and demonstrate its analytical utility by systematically isolating key factors, showing that (i) user mediation compounds the inherent difficulty of social reasoning; (ii) LLMs exhibit systematic sensitivity to biased user framing; (iii) models can require more details than humans need to reach a correct prediction; and (iv) longer conversations do not always improve performance despite providing opportunities for clarifying questions. We open-source Fuse and a dataset with 21k examples.
Unauthorized hardware replacement can preserve a wireless device's logical identity while altering its physical implementation, posing a challenge to hardware integrity verification. Spatio-frequency polarization fingerprints (SFPFs) capture device-dependent responses across multiple frequencies and directions, but their frequency and spatial dimensions exhibit different structural dependencies. We propose FreqSpaNet, an SFPF representation learning network for open set hardware anomaly detection. A frequency branch captures local variations among neighboring frequencies, while a geometry-aware spatial branch models directional relationships using angular information. The two representations are combined through adaptive fusion, and complementary pretraining further captures shared information while preserving the distinct characteristics of the frequency and spatial representations. Experiments show that FreqSpaNet achieves a mean AUROC of 96.31\%, 9.05 points above the baseline. Results under seven hardware replacement scenarios further verify the effectiveness of FreqSpaNet.
We introduce LimiX-2, a new model in the LimiX family, developed through model and data scaling guided by our previously established scaling laws. LimiX-2 adopts the Contextual Mechanism Networks (CMNs) paradigm and is pretrained with Context-Conditional Masked Modeling (CCMM). CMNs shifts the organizing principle of in-context learning from target-centric prediction to mechanism-oriented joint modeling. Rather than centering the network on the $p(y \mid x, D_{\mathrm{context}})$ objective of conventional tabular PFNs, it is designed around learning $p(x, y \mid D_{\mathrm{context}})$, a context-dependent representation of the joint structure underlying data generation. Pretraining uses synthetic datasets generated by structural causal models (SCMs) spanning diverse graph structures, functional mechanisms, and observation processes. Evaluations on TabArena, TALENT, and BCCO show that LimiX-2 outperforms current dataset-specific models and tabular foundation models. Beyond predictive performance, the CMN paradigm also promotes causal awareness in LimiX-2: its feature attention encodes direct causal relationships, enabling accurate causal skeleton recovery.
Modern large-scale machine learning tasks often require multiple workers, devices, CPUs, or GPUs to compute stochastic gradients in parallel and asynchronously to train model weights. Theoretical results typically distinguish between two settings: (i) the homogeneous setting, where all workers have access to the same data distribution, and (ii) the heterogeneous setting, where each worker operates on different data distributions. Known optimal time complexities in these settings reveal a significant gap, with far more pessimistic guarantees in the heterogeneous case. In this work, we investigate whether these pessimistic optimal time complexities can be overcome under different assumptions. Surprisingly, we show that improvement is provably impossible under widely used first- and second-order similarity assumptions for any randomized algorithm. We then turn to the interpolation regime and demonstrate that the weak interpolation assumption alone is also insufficient. Finally, we introduce a minimal combination of irreducible assumptions, strong interpolation and the local Polyak-Lojasiewicz condition, to derive a new time complexity bound that matches the dependence on worker computation times in the best-known result in the homogeneous setting, without requiring identical data distributions.
Despite the rapid uptake of black-box object detectors in marine mammal research and monitoring, explainability techniques are rarely integrated into conservation workflows. Furthermore, most classification-oriented explainability tools are ill-suited to detection tasks involving imagery of social organisms or those with colonial life histories, as they ignore multiple detections within a scene and produce single-instance outputs that blur evidence across individuals. These methods also generate low-resolution, often biologically irrelevant visuals, limiting their utility for debugging, targeted data augmentation, and refined data collection. We proposed Det-LIME, a detector-aware, multi-instance adaptation of Local Interpretable Model-Agnostic Explanations (LIME) that produced instance-specific, box-aligned explanations by combining per-detection weighting, a proximity kernel that emphasizes regions near each box, and Intersection-over-Union-based matching to track the same instance across perturbations. We evaluated Det-LIME on aerial drone imagery for harbor seal detection, with an additional seabird case study to assess generality, and compared it with vanilla LIME, Stabilized LIME, Deterministic LIME, and gradient-based attribution methods. Using the Attribution Ratio and Max Saliency Hit Rate metrics, we showed that Det-LIME consistently improved multi-instance attribution. In practice, these higher-resolution, instance-aware explanations provide insight into model outputs and support post-processing, debugging, and actionable improvements in modeling and data collection or augmentation.
The absolute capacity of dense associative memory has mainly been analyzed for unbiased patterns. Here we examine the effect of bias in centered binary patterns under the Krotov-Hopfield single-site criterion $P_{\mathrm{error}}=1/N$, where $P_{\mathrm{error}}$ is the probability that a single-site flip lowers the energy of a stored pattern and $N$ is the number of neurons. Each pattern component takes $1-q$ with probability $q$ and $-q$ otherwise, where $0<q\le1/2$. For polynomial interactions of order $n$, a signal-to-noise analysis gives an absolute capacity of order $N^{n-1}/\ln N$ at $q=1/2$. For fixed $q<1/2$, however, the capacity is $O(N^{n/2})$ for even $n\ge4$ and $O(N^{(n+1)/2})$ for odd $n\ge5$. For $n=3$, both the unbiased and fixed-bias capacities remain $O(N^2/\ln N)$. For $n\ge4$, these different asymptotic forms imply a nonuniform large-$N$ limit near $q=1/2$. Asymptotic matching predicts a bias-induced crossover in the region $1-2q=O(\ln N/N^{\lfloor n/2\rfloor-1})$. The crossover originates from a bias-dependent crosstalk mean that reduces the stability of sites carrying the more frequent value $-q$. Computer simulations are compared with the finite-size conditioned-Gaussian predictions. An activity-dependent control potential that cancels the conditional crosstalk mean restores the $N^{n-1}/\ln N$ capacity for fixed $0<q<1/2$ within the conditioned-Gaussian approximation.
Capable open-weight models make local coding and reasoning attractive, but their context and execution state strain laptop memory. We present JustFit, an MLX-based inference runtime that combines KVExec for compressed KV execution, PhaseSwap for component residency, and StateTrans for state-preserving serving transitions. These mechanisms fuse reconstruction and coordinate just-in-time materialization and release, independently of model-weight quantization. In full-execution capacity tests on a 24 GiB M4 Pro MacBook running Qwen3.8-27B MXFP4, three independent runs complete 196,608 input and 16,384 output tokens, increasing completed single-request context from the mlx-vlm baseline's 30,720 positions to 212,992 (6.93x); a separate two-request run retains 229,376 positions in aggregate. In separate performance tests, a 32K-input, 64-output probe reaches 19.11 tokens/s, and a repeated 32K+6K workload has a median peak process footprint of 16,374 MiB. The integrated runtime answers 29 of 30 AIME 2026 problems correctly, showing how compact state and lifetime-aware execution expand local serving capacity while supporting extended generated reasoning.
Large language model (LLM) distillation aims to transfer the capabilities of a powerful teacher to a smaller student. Direct imitation, however, can also transfer the teacher's systematic bias and errors. This challenge is particularly pronounced under covariate shift, when the teacher's reliability on target questions is uncertain and target-domain reward feedback is unavailable. We propose Coupled Calibration and Learning (CCL), an LLM distillation algorithm that couples teacher calibration with student updates through token-level branching, using reward feedback only on source questions. Each iteration calibrates the teacher using source feedback and then uses the calibrated teacher to train the student on target questions. The updated student, in turn, informs subsequent calibration. In an autoregressive policy framework, we prove that the output student's expected average Kullback-Leibler divergence to the oracle student converges to zero at a polynomial rate in the number of iterations. The oracle maximizes the true reference-regularized target reward within the student class, which need not represent the unrestricted optimal policy. Our analysis quantifies the progress of projected student gradient updates while controlling the error in teacher calibration. We further establish a separation from regularized direct matching: its error relative to the oracle student can remain bounded away from zero even when the teacher achieves higher regularized target reward than every student policy. These results demonstrate that LLM distillation can overcome persistent teacher bias and recover the optimal student through coupled calibration and learning, without target-domain reward feedback.
Multi-agent systems split a task across a tree of agents and justify the split with folklore: smaller contexts, cleaner separation, parallelism. We ask what the split does to how much of what the leaves discover reaches the root. Model a decomposition as a tree in which an agent handed $b$ items keeps any one with probability $r(b)$. If $r(b)=1/b$, every tree delivers exactly one finding, for every task size and every shape; we verify this to $2.4 \times 10^{-15}$ on 20,000 random irregular trees. If $r(b)=Cb^{-δ}$, a depth-$k$ tree over $N$ findings yields $C^k N^{1-δ}$: task size and architecture separate, and architecture contributes only $C \le 1$ per level, so flat is optimal for yield and no arrangement of agents escapes the exponent $δ$. On 600 production deep-research traces $δ= 0.34$ [0.30, 0.38], by three identifications that do not share a failure mode. At a hop where item boundaries come from the tool rather than a text heuristic, and where $b=1$ occurs 550 times, $C = 0.571$ [0.527, 0.615] is observed rather than extrapolated, over 16,082 hops. A tier also costs alignment: on 1,012 annotated multi-agent traces one brief in sixteen goes off-target, giving $μ= 0.939$ and a per-tier penalty $Cμ= 0.536$. Depth is bought on two other axes. The root context is the only state that persists and the only one that cannot cheaply forget, and depth cuts its exposure from $N$ items to $N^{1/k}$. Depth is also cheaper: production flat agents bill as $N^{1.39}$, not the $N^2$ an append-only context predicts, and at equal spend two tiers overtake flat at 403 findings. Across every parameter we measured the model says 0.7% to 11.3% of production sessions are worth delegating, against 7.8% that do. A hazard model on 743,819 production tool calls finds that delegation does not respond to a filling context and is instead an opening move.